Bone Abstracts

While a strong emphasis has been put on the characteristics of trabecular bone due to its’ high metabolic rate, the human skeleton actually consists of ~80% cortical bone. Furthermore, the cortical bone supports a major proportion of the mechanical load (i.e. upto 96%) at common fracture sites, such as the base of the femoral neck and the intertrochanteric region. In these regions of the hip, large compressive stresses concentrate during walking as well as during falls an...

While a strong emphasis has been put on the characteristics of trabecular bone due to its’ high metabolic rate, the human skeleton actually consists of approximately 80% cortical bone. Furthermore, the cortical bone supports a major proportion of the mechanical load (i.e., up to 96%) at common fracture sites, such as the base of the femoral neck and the intertrochanteric region. In these regions of the hip, large compressive stresses concentrate during walking as well as ...

Biographical DetailsBjörn BusseBjörn Busse is currently head of a ‘Emmy Noether Research Group’ (eq. Assistant Professor) which is a prestigious 5 year-program run by the German Research Foundation (DFG). The group of Björn is hosted by the Department of Osteology and Biomechanics at the University Medical Center Hamburg-Epp...

Although the fracture risk reduction under bisphosphonate treatment in osteoporosis is clinically well established, it remains understudied why the efficacy of bisphosphonate therapy is higher for the prevention of vertebral fractures compared to other fractures.Our aim was to investigate whether anti-resorptive therapy with alendronate would result in different regional variations of structural indices in the vertebral body. We investigated the microstr...

Introduction: Aging, diabetes and other disease conditions are associated with the accumulation of non-enzymatic collagen cross-links (NE-XL) in human tissues. Non-enzymatic cross-links (i.e. advanced glycation end products (AGEs)), occur at the bone collagen level, where they are associated with individuals increased fracture risk caused by bone’s reduced plasticity.Methods: Here, non-destructive Fourier-transform infrared (FTIR) spectroscopy was u...

Objectives: Osteogenesis imperfecta (OI) is a heritable disorder characterized by bone deformity and skeletal fragility. Cartilage associated protein (CRTAP), proline 3-Hydroxylase 1 (P3H1) and Cyclophylin B (PPIB) are components of the endoplasmic reticulum (ER)-resident complex involved in the 3-hydroxylation of specific proline residues in collagen type I α chains. Mutations in these proteins are responsible for recessive OI type VII, VIII and IX, respectively. Murine ...